Obesity of the mother accelerates the aging of offspring

Obesity of the mother accelerates the aging of offspring

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How the weight of the mother affects the health of her offspring

Overweight and obesity (obesity) are known to affect metabolism. The latest research now shows that the effects of maternal obesity are passed on to the offspring even across generations, accelerate the rate of aging and promote metabolic problems.

The latest joint study by the University of Wyoming and the Salvador Zubiran National Institute of Medical Sciences and Nutrition in Mexico City found that the effects of maternal obesity on generations to inherit, causing serious health problems and faster aging favor. The results of the study were published in the English-language journal "Journal of Physiology".

Maternal obesity also affects children

Obesity affects our metabolism and increases the risk of diabetes and heart disease. Researchers have now found that obesity affects not only the metabolism of mothers themselves, but also those of future generations. Maternal obesity affects the aging and related metabolic problems of the offspring.

Offspring diabetes risk from obese mothers

The study examined the offspring of obese rat mothers. The researchers monitored these offspring throughout their lives. So they wanted to determine the rate at which the animals aged. The offspring of obese mothers had more body fat and showed early prediabetic signs, such as an early increase in insulin resistance, which increased the likelihood of diabetes, the researchers report.

Effects were partly dependent on gender

The offspring of the obese mothers showed impaired function of their mitochondria. These changes increase the likelihood of developing heart disease. Interestingly, some of the undesirable outcomes that resulted from maternal obesity were different in male and female offspring. The reason for this is still unclear, but it is believed that it is a hormonal effect. It was encouraging to see that movement in offspring offset some of the negative effects that mother obesity has, the research group reports.

Fetus fatty liver from obese mother?

"The new findings help to demonstrate the impact of uterine and early life conditions on health and offspring susceptibility to disease throughout life," study author Peter Nathanielsz of the University of Wyoming said in a press release . For example, previous research by the research group showed that an obese pregnant mother and exposure to a high-fat, high-sugar diet during pregnancy can cause fatty liver in the fetus. Affected children may also have an increased risk of obesity, metabolic and cardiovascular diseases later in life. (as)

Author and source information

This text corresponds to the specifications of the medical literature, medical guidelines and current studies and has been checked by medical doctors.


  • Guadalupe L. Rodríguez ‐ González, Luis A. Reyes ‐ Castro, Claudia J. Bautista, Azucena A. Beltrán, Carlos A. Ibáñez et al .: Maternal obesity accelerates rat offspring metabolic aging in a sex dependent manner, in Journal of Physiology ( Query: 10.10.2019), Journal of Physiology
  • UW Researcher Shows That Maternal Obesity Speeds Up Aging in Offspring, University of Wyoming (query: 10.10.2019), University of Wyoming

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